SORL1

Across TCGA pan-cancer cohorts, SORL1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SORL1 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SORL1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SORL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, DLBC, and LUSC are the cancer types where SORL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.860	0.609	<.001	36	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	33	view →
LUSC	OS	Median	III,IV	0.001	0.684	<.001	28	view →
HNSC	OS	Median	II,III,IV	0.270	0.715	.014	15	view →
PRAD	DFS	Median	All	0.508	0.936	<.001	12	view →
BLCA	OS	Median	III,IV	0.874	0.346	.017	9	view →
LIHC	DFS	Median	All	1.000	0.293	.026	9	view →
SARC	DFS	Median	All	0.179	0.612	.024	6	view →
LUAD	DFS	Median	II,III,IV	0.325	0.723	.029	6	view →
GBM	OS	Median	All	0.121	0.415	.042	3	view →
ACC	DFS	Median	III,IV	1.000	0.274	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SORL1–UCEC (DFS)

Open the UCEC breakdown →