SORL1

Across TCGA pan-cancer cohorts, SORL1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SORL1 data layer compared with 24 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SORL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SORL1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC and CCRCC are the cancer types where SORL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.594	0.168	.001	15	view →
CCRCC	DFS	Tertile	All	0.872	0.436	.014	5	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SORL1–PDAC (DFS)

Open the PDAC breakdown →