SORD

Across TCGA patient cohorts, SORD mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORD-associated genes across cancer lineages are MAPK_pT202_Y204, MEK1_p_S217_S221, and CD20. Each is linked with SORD in more than 1 cancer types. Because this analysis shows association rather than direction, both SORD-to-partner and partner-to-SORD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by SORD-low versus SORD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORD→partner) and Y-score (partner→SORD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.558	-3.000	.023	.036	3	1
UCEC	MEK1_p_S217_S221 →	-0.355	-3.000	.013	.036	3	1
UCEC	CD20 →	+0.144	+3.020	.036	.019	3	1
UCEC	C-Raf_pS338 →	-0.094	-2.950	.027	.036	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MAPK_pT202_Y204 by SORD expression — UCEC

Explore this box plot interactively →