SORD

Across TCGA cell cohorts, SORD RNA expression is significantly associated with the go_rna of many other GO terms, with 5,000 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SORD-associated GO terms across cancer lineages are D-glucuronate catabolic process to D-xylulose 5-phosphate, D-glucuronate catabolic process, and Glucuronate catabolic process. Each is linked with SORD in more than 17 cancer types. Because this analysis shows association rather than direction, both SORD-to-partner and partner-to-SORD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, D-glucuronate catabolic process to D-xylulose 5-phosphate grouped by SORD-low versus SORD-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SORD→partner) and Y-score (partner→SORD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	D-glucuronate catabolic process to D-xylulose 5-phosphate →	+0.345	+2.257	<.001	<.001	3	18
LUNG_NSCLC_LUSC	D-glucuronate catabolic process →	+0.345	+2.257	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Glucuronate catabolic process →	+0.345	+2.257	<.001	<.001	3	18
LIVER	Glucuronate metabolic process →	+0.172	+1.481	<.001	<.001	3	16
BONE	D-xylulose 5-phosphate metabolic process →	+0.265	+2.289	<.001	<.001	3	16
OESOPHAGUS	Polyol catabolic process →	+0.140	+1.218	.003	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,000 associations by consensus.

D-glucuronate catabolic process to D-xylulose 5-phosphate by SORD expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →