Across TCGA patient cohorts, SORCS2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,417 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SORCS2-associated genes across cancer lineages are IGDCC4, SEPTIN4, and PXDN. Each is linked with SORCS2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SORCS2-to-partner and partner-to-SORCS2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS2→partner) and Y-score (partner→SORCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IGDCC4 →	+0.796	+0.600	<.001	<.001	3	6
GBM	SEPTIN4 →	+0.900	+0.401	<.001	<.001	3	6
BRCA	PXDN →	+1.431	+1.070	<.001	<.001	3	6
BRCA	EDA2R →	+0.990	+0.680	<.001	<.001	3	6
GBM	SHISAL1 →	+1.234	+0.510	<.001	<.001	3	6
PDAC	ABCA8 →	+1.077	+0.554	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,417 associations by consensus.

Exploration

SORCS2 survival (RNA) · tumor vs normal (RNA) · all SORCS2 data types