Across TCGA patient cohorts, SORCS2 mutation is significantly associated with the RNA expression of many other genes, with 2,363 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORCS2-associated genes across cancer lineages are MIR4510, SNORD37, and RNA5SP369. Each is linked with SORCS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SORCS2-to-partner and partner-to-SORCS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS2→partner) and Y-score (partner→SORCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4510 →	+0.196	+4.342	<.001	.007	3	3
SKCM	SNORD37 →	+0.330	+2.135	.009	<.001	3	3
UCEC	RNA5SP369 →	+0.194	+1.405	.003	.004	3	3
UCEC	CDCA2 →	+0.486	+1.673	.002	.002	3	3
UCEC	LINC01047 →	+0.058	+1.271	.008	.004	3	3
LUAD	OR6C7P →	+0.039	+4.263	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,363 associations by consensus.

Exploration

SORCS2 survival (RNA) · tumor vs normal (RNA) · all SORCS2 data types