Across TCGA cell cohorts, SORCS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,349 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SORCS2-associated GO terms across cancer lineages are Gliogenesis, Acrosomal vesicle exocytosis, and Plasma membrane organization. Each is linked with SORCS2 in more than 10 cancer types. Because this analysis shows association rather than direction, both SORCS2-to-partner and partner-to-SORCS2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS2→partner) and Y-score (partner→SORCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Gliogenesis →	+0.093	+1.926	<.001	<.001	3	10
SKIN	Acrosomal vesicle exocytosis →	-1.032	-1.109	<.001	.006	3	10
BONE	Plasma membrane organization →	+0.150	+1.772	.001	.006	3	10
URINARY_TRACT	Glial cell differentiation →	+0.086	+1.511	<.001	.002	2	11
BREAST	Regulation of cell-substrate adhesion →	+0.076	+1.353	<.001	<.001	3	9
SKIN	Positive regulation of ATP biosynthetic process →	+0.155	+0.851	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,349 associations by consensus.

Exploration

SORCS2 survival (RNA) · tumor vs normal (RNA) · all SORCS2 data types