Across TCGA cell cohorts, SORCS2 mutation is significantly associated with the RNA expression of many other genes, with 132 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SORCS2-associated genes across cancer lineages are OR2V2, SPATA31A6, and FABP9. Each is linked with SORCS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SORCS2-to-partner and partner-to-SORCS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS2→partner) and Y-score (partner→SORCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2V2 →	+0.029	+3.544	<.001	.009	3	2
URINARY_TRACT	SPATA31A6 →	+0.005	+4.087	<.001	.009	3	1
URINARY_TRACT	FABP9 →	+0.042	+4.087	<.001	.009	3	1
LUNG_NSCLC_LUAD	AVP →	+0.031	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	GABRA6 →	+0.076	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.020	+5.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 132 associations by consensus.

Exploration

SORCS2 survival (RNA) · tumor vs normal (RNA) · all SORCS2 data types