SORCS1

Across TCGA patient cohorts, SORCS1 mutation is significantly associated with the RNA expression of many other genes, with 8,343 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORCS1-associated genes across cancer lineages are CHEK1, KIF23, and KIF11. Each is linked with SORCS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SORCS1-to-partner and partner-to-SORCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by SORCS1-low versus SORCS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS1→partner) and Y-score (partner→SORCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.565	+1.234	<.001	<.001	3	7
LUAD	KIF23 →	+0.786	+1.402	<.001	<.001	3	7
UCEC	KIF11 →	+0.623	+1.351	<.001	<.001	3	7
READ	UTP11 →	+0.591	+3.450	.005	.003	3	6
UCEC	SKA1 →	+0.682	+1.730	<.001	<.001	3	6
LUAD	BUB1B →	+0.777	+1.378	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,343 associations by consensus.

CHEK1 by SORCS1 expression — UCEC

Explore this box plot interactively →