SORCS1

Across TCGA patient cohorts, SORCS1 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORCS1-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with SORCS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SORCS1-to-partner and partner-to-SORCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SORCS1-low versus SORCS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS1→partner) and Y-score (partner→SORCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.248	+1.523	<.001	.005	3	5
UCEC	Cyclin-B1 →	+0.640	+1.969	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.667	+1.304	<.001	<.001	3	4
LUAD	FoxM1 →	+0.232	+1.405	<.001	.009	3	3
UCEC	PCNA →	+0.213	+1.678	<.001	<.001	3	3
LUAD	TFRC →	+0.483	+1.222	<.001	.029	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

4E-BP1 by SORCS1 expression — UCEC

Explore this box plot interactively →