SORCS1

Across TCGA cell cohorts, SORCS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,326 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SORCS1-associated GO terms across cancer lineages are Positive regulation of DNA repair, Transcription initiation at RNA polymerase II promoter, and Negative regulation of cellular response to insulin stimulus. Each is linked with SORCS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SORCS1-to-partner and partner-to-SORCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by SORCS1-low versus SORCS1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS1→partner) and Y-score (partner→SORCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of DNA repair →	+0.068	+2.202	<.001	.002	3	6
SOFT_TISSUE	Transcription initiation at RNA polymerase II promoter →	+0.057	+1.810	<.001	.001	3	6
SKIN	Negative regulation of cellular response to insulin stimulus →	+0.069	+1.430	<.001	<.001	3	6
BONE	Positive regulation of T-helper 17 cell lineage commitment →	+0.140	+0.344	.003	.009	3	5
SOFT_TISSUE	DNA-templated transcription initiation →	+0.057	+2.099	<.001	<.001	3	5
SKIN	Viral translational termination-reinitiation →	+0.049	+1.470	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,326 associations by consensus.

Positive regulation of DNA repair by SORCS1 expression — SOFT_TISSUE

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