SORCS1

Across TCGA cell cohorts, SORCS1 mutation is significantly associated with the RNA expression of many other genes, with 405 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SORCS1-associated genes across cancer lineages are PTTG2, RPUSD4, and NOC3L. Each is linked with SORCS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SORCS1-to-partner and partner-to-SORCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTTG2 grouped by SORCS1-low versus SORCS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS1→partner) and Y-score (partner→SORCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTTG2 →	+0.060	+2.949	.001	<.001	3	3
LUNG_SCLC	RPUSD4 →	+0.434	+3.459	.006	.002	3	2
LUNG_SCLC	NOC3L →	+0.542	+3.252	.002	.002	3	2
OVARY	PRR23C →	+0.009	+3.990	<.001	.003	3	2
LARGE_INTESTINE	DTWD1 →	+0.545	+2.265	.001	.001	3	2
LARGE_INTESTINE	CDC73 →	+0.533	+3.169	.004	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 405 associations by consensus.

PTTG2 by SORCS1 expression — LARGE_INTESTINE

Explore this box plot interactively →