SORBS1

Across TCGA patient cohorts, SORBS1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,301 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SORBS1-associated genes across cancer lineages are SEPTIN4, SPARCL1, and LMOD1. Each is linked with SORBS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SORBS1-to-partner and partner-to-SORBS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SORBS1 versus SEPTIN4 in CCRCC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS1→partner) and Y-score (partner→SORBS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEPTIN4 →	+0.715	+0.707	<.001	<.001	3	10
UCEC	SPARCL1 →	+1.475	+0.781	<.001	<.001	3	10
UCEC	LMOD1 →	+1.706	+0.934	<.001	<.001	3	10
COAD	MYLK →	+1.300	+0.965	<.001	<.001	3	10
UCEC	IRAG1 →	+1.053	+0.875	<.001	<.001	3	10
UCEC	MYL9 →	+1.279	+0.755	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,301 associations by consensus.

SORBS1 vs SEPTIN4 — CCRCC

Explore this scatter interactively →