SORBS1

Across TCGA patient cohorts, SORBS1 mutation is significantly associated with the RNA expression of many other genes, with 5,365 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORBS1-associated genes across cancer lineages are PPP2R2D, CDCA5, and TMEM120B. Each is linked with SORBS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SORBS1-to-partner and partner-to-SORBS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R2D grouped by SORBS1-low versus SORBS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS1→partner) and Y-score (partner→SORBS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP2R2D →	+0.297	+1.758	<.001	<.001	3	4
UCEC	CDCA5 →	+0.741	+1.964	<.001	<.001	3	4
SKCM	TMEM120B →	+0.332	+2.204	.003	.008	3	3
UCEC	COX15 →	+0.447	+2.192	<.001	<.001	3	3
UCEC	VTI1A →	+0.354	+1.975	<.001	<.001	3	3
UCEC	ADK →	+0.354	+1.390	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,365 associations by consensus.

PPP2R2D by SORBS1 expression — UCEC

Explore this box plot interactively →