SORBS1

Across TCGA patient cohorts, SORBS1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORBS1-associated genes across cancer lineages are Rictor_pT1135, TFRC, and ATM. Each is linked with SORBS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SORBS1-to-partner and partner-to-SORBS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by SORBS1-low versus SORBS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS1→partner) and Y-score (partner→SORBS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.088	-2.115	.007	.016	3	3
UCEC	TFRC →	+0.517	+2.807	.002	.002	3	3
UCEC	ATM →	-0.577	-2.058	<.001	<.001	3	3
COAD	eEF2 →	+0.364	+2.815	.025	.036	3	2
UCEC	Cyclin-B1 →	+0.673	+2.999	<.001	<.001	3	2
UCEC	Notch1 →	+0.229	+3.335	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Rictor_pT1135 by SORBS1 expression — UCEC

Explore this box plot interactively →