SON

Across TCGA pan-cancer cohorts, SON Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SON data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SON Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SON expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

THYM, KIRC, and UCEC are the cancer types where SON Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
KIRC	OS	Median	II,III,IV	0.221	0.789	.016	30	view →
UCEC	DFS	Median	II,III,IV	0.911	0.293	.001	28	view →
STAD	DFS	Median	All	0.762	0.388	.015	21	view →
OV	OS	Median	IV	0.076	0.759	.014	12	view →
LGG	DFS	Median	All	0.443	0.834	<.001	8	view →
PRAD	DFS	Median	All	0.617	0.886	.035	6	view →
LIHC	DFS	Median	III,IV	0.040	0.361	<.001	6	view →
LUAD	OS	Median	III,IV	1.000	0.483	.034	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
READ	DFS	Median	IV	0.255	0.628	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SON–THYM (OS)

Open the THYM breakdown →