SON

Across TCGA patient cohorts, SON mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SON-associated genes across cancer lineages are PCNA, eEF2, and GAPDH. Each is linked with SON in more than 3 cancer types. Because this analysis shows association rather than direction, both SON-to-partner and partner-to-SON results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SON-low versus SON-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SON→partner) and Y-score (partner→SON) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.319	+3.169	.018	.018	2	4
UCEC	eEF2 →	+0.229	+1.662	.012	.009	3	3
UCEC	GAPDH →	+0.310	+1.064	.025	.043	3	3
UCEC	Rad50 →	-0.149	-0.830	.017	.049	3	3
UCEC	STAT3_pY705 →	-0.300	-1.087	<.001	.010	3	3
COAD	ATM →	-0.601	-3.459	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

PCNA by SON expression — STAD

Explore this box plot interactively →