SON

Across TCGA cell cohorts, SON RNA expression is significantly associated with the go_rna of many other GO terms, with 4,200 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SON-associated GO terms across cancer lineages are Protein localization to nucleus, Nuclear export, and Protein sumoylation. Each is linked with SON in more than 17 cancer types. Because this analysis shows association rather than direction, both SON-to-partner and partner-to-SON results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nucleus grouped by SON-low versus SON-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SON→partner) and Y-score (partner→SON) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Protein localization to nucleus →	+0.065	+1.125	<.001	.001	3	18
SOFT_TISSUE	Nuclear export →	+0.087	+0.935	.002	.001	3	18
STOMACH	Protein sumoylation →	+0.092	+0.613	<.001	.004	3	17
OESOPHAGUS	RNA export from nucleus →	+0.130	+0.686	.006	.006	3	16
BLOOD_Myeloma	Nucleocytoplasmic transport →	+0.072	+0.946	.001	<.001	3	16
SOFT_TISSUE	Microtubule cytoskeleton organization involved in mitosis →	+0.083	+0.822	.007	.004	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,200 associations by consensus.

Protein localization to nucleus by SON expression — UPPER_AERODIGESTIVE_TRACT

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