SON

Across TCGA cell cohorts, SON mutation is significantly associated with the RNA expression of many other genes, with 453 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SON-associated genes across cancer lineages are LCE6A, DUXA, and CFHR2. Each is linked with SON in more than 1 cancer types. Because this analysis shows association rather than direction, both SON-to-partner and partner-to-SON results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE6A grouped by SON-low versus SON-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SON→partner) and Y-score (partner→SON) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LCE6A →	+0.227	+3.700	.001	.009	3	2
SOFT_TISSUE	DUXA →	+0.070	+3.295	.003	.006	3	2
CNS	CFHR2 →	+0.038	+4.357	<.001	.004	3	2
SKIN	OR4X2 →	+0.016	+3.760	<.001	<.001	3	2
BLOOD_Leukemia	SLC32A1 →	+0.496	+1.901	<.001	.008	3	2
BLOOD_Leukemia	SARAF →	+0.488	+3.730	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 453 associations by consensus.

LCE6A by SON expression — SKIN

Explore this box plot interactively →