SOHLH2

Across TCGA cell cohorts, SOHLH2 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOHLH2-associated genes across cancer lineages are S100G, OR2T5, and C1orf141. Each is linked with SOHLH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOHLH2-to-partner and partner-to-SOHLH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100G grouped by SOHLH2-low versus SOHLH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOHLH2→partner) and Y-score (partner→SOHLH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	S100G →	+0.823	+2.688	.001	.002	3	2
BREAST	OR2T5 →	+0.033	+5.781	<.001	.001	3	1
BREAST	C1orf141 →	+0.049	+5.781	<.001	.001	3	1
BREAST	FOXB2 →	+0.042	+5.169	<.001	.005	3	1
BLOOD_Leukemia	PHOX2B →	+0.023	+4.950	<.001	<.001	3	1
BLOOD_Leukemia	IL2 →	+0.554	+3.106	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

S100G by SOHLH2 expression — LARGE_INTESTINE

Explore this box plot interactively →