SOGA1

Across TCGA pan-cancer cohorts, SOGA1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated SOGA1 data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SOGA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SOGA1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCEC show a favorable association.

OV, ESCA, and BLCA are the cancer types where SOGA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.400	0.847	<.001	36	view →
ESCA	OS	Median	All	0.129	0.704	<.001	36	view →
BLCA	OS	Median	III,IV	0.057	0.684	<.001	18	view →
COAD	OS	Median	All	0.181	0.806	.002	14	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	12	view →
LUSC	DFS	Median	All	0.788	0.366	.010	10	view →
SKCM	DFS	Median	IV	0.016	0.454	<.001	6	view →
LIHC	DFS	Median	II,III,IV	0.114	0.431	.017	6	view →
UCEC	DFS	Median	All	0.942	0.827	.026	4	view →
PRAD	DFS	Median	All	0.161	0.777	<.001	4	view →
SARC	DFS	Median	All	0.210	0.612	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SOGA1–OV (OS)

Open the OV breakdown →