SOGA1

Across TCGA pan-cancer cohorts, SOGA1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SOGA1 data layer compared with 26 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SOGA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SOGA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

PDAC, HNSC, and GBM are the cancer types where SOGA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.607	0.829	.008	20	view →
HNSC	OS	Median	II,III,IV	0.990	0.937	.034	12	view →
GBM	OS	Quartile	All	0.671	0.297	.013	7	view →
OV	DFS	Median	All	0.845	1.000	.019	4	view →
LUAD	DFS	Median	All	0.677	0.951	.020	4	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.690	.016	4	view →
CCRCC	OS	Median	All	0.902	0.756	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SOGA1–PDAC (DFS)

Open the PDAC breakdown →