SOD3

Across TCGA pan-cancer cohorts, SOD3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SOD3 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SOD3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SOD3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, UCEC, and LUAD are the cancer types where SOD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.650	0.429	<.001	91	view →
UCEC	DFS	Quartile	II,III,IV	0.387	1.000	.015	24	view →
LUAD	DFS	Median	III,IV	0.426	0.976	.002	21	view →
CCRCC	DFS	Quartile	II,III,IV	0.176	1.000	.024	15	view →
HNSC	OS	Median	II,III,IV	0.953	1.000	.019	8	view →
LSCC	DFS	Median	III,IV	0.932	0.653	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SOD3–PDAC (OS)

Open the PDAC breakdown →