SOD3

Across TCGA patient cohorts, SOD3 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOD3-associated genes across cancer lineages are RNA5SP461, RNU6-1015P, and MIR6870. Each is linked with SOD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOD3-to-partner and partner-to-SOD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP461 grouped by SOD3-low versus SOD3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOD3→partner) and Y-score (partner→SOD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP461 →	+0.468	+7.816	<.001	.008	3	1
SKCM	RNU6-1015P →	+0.368	+7.816	<.001	.008	3	1
UCEC	MIR6870 →	+0.449	+3.344	.008	.008	3	1
UCEC	LINC01926 →	+0.421	+3.548	.005	.007	3	1
UCEC	BORCS7-ASMT →	+0.013	+4.923	<.001	.002	3	1
UCEC	SNORD37 →	+0.901	+3.298	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

RNA5SP461 by SOD3 expression — SKCM

Explore this box plot interactively →