Across TCGA pan-cancer cohorts, SOD1P2 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SOD1P2’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where SOD1P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SOD1P2 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
COAD, LUAD, and KIRC are the cancer types where SOD1P2 tumor–normal differential expression is most reproducible.