SOCS6

Across TCGA pan-cancer cohorts, SOCS6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SOCS6 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SOCS6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SOCS6 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

GBM, PDAC, and CCRCC are the cancer types where SOCS6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.463	0.267	.006	12	view →
PDAC	OS	Median	All	0.237	0.683	.047	6	view →
CCRCC	DFS	Median	All	0.493	0.892	.017	5	view →
LSCC	DFS	Median	All	0.420	0.907	.006	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SOCS6–GBM (DFS)

Open the GBM breakdown →