SOCS6

Across TCGA patient cohorts, SOCS6 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOCS6-associated genes across cancer lineages are EGFR_pY1068, ATM, and Cyclin-D1. Each is linked with SOCS6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOCS6-to-partner and partner-to-SOCS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SOCS6-low versus SOCS6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS6→partner) and Y-score (partner→SOCS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.268	-2.999	<.001	<.001	3	3
UCEC	ATM →	-0.553	-2.649	<.001	<.001	3	3
CESC	Cyclin-D1 →	+0.291	+3.000	.032	.033	3	2
UCEC	PDCD4 →	-0.412	-1.352	.003	.034	3	2
COAD	ASNS →	+0.589	+3.593	<.001	.001	3	2
COAD	Chk2_pT68 →	-0.155	-3.157	.030	.018	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

EGFR_pY1068 by SOCS6 expression — UCEC

Explore this box plot interactively →