SOCS6

Across TCGA cell cohorts, SOCS6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,822 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SOCS6-associated GO terms across cancer lineages are ESCRT complex disassembly, ESCRT III complex disassembly, and Viral release from host cell. Each is linked with SOCS6 in more than 8 cancer types. Because this analysis shows association rather than direction, both SOCS6-to-partner and partner-to-SOCS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESCRT complex disassembly grouped by SOCS6-low versus SOCS6-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS6→partner) and Y-score (partner→SOCS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ESCRT complex disassembly →	+0.124	+1.324	.002	.002	3	9
LUNG_NSCLC_LUSC	ESCRT III complex disassembly →	+0.124	+1.324	.002	.002	3	9
LUNG_NSCLC_LUSC	Viral release from host cell →	+0.107	+1.219	.001	.004	3	9
LUNG_NSCLC_LUSC	Exit from host cell →	+0.107	+1.219	.001	.004	3	9
LUNG_NSCLC_LUSC	Viral budding from plasma membrane →	+0.124	+1.418	.004	.008	3	9
LARGE_INTESTINE	Endosome to lysosome transport via multivesicular body sorting pathway →	+0.108	+0.969	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,822 associations by consensus.

ESCRT complex disassembly by SOCS6 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →