SOCS6

Across TCGA cell cohorts, SOCS6 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOCS6-associated genes across cancer lineages are CSN2, ECE2, and VWC2L. Each is linked with SOCS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS6-to-partner and partner-to-SOCS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by SOCS6-low versus SOCS6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS6→partner) and Y-score (partner→SOCS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSN2 →	+0.031	+3.684	<.001	.006	3	1
LARGE_INTESTINE	ECE2 →	+0.340	+4.054	<.001	.004	3	1
LARGE_INTESTINE	VWC2L →	+0.011	+3.930	<.001	.003	3	1
LARGE_INTESTINE	DBX2 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	CASP12 →	+0.033	+3.684	<.001	.006	3	1
LARGE_INTESTINE	OR2J1 →	+0.004	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

CSN2 by SOCS6 expression — LARGE_INTESTINE

Explore this box plot interactively →