SOCS5

Across TCGA pan-cancer cohorts, SOCS5 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated SOCS5 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SOCS5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SOCS5 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BRCA, OV, and SKCM are the cancer types where SOCS5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.350	0.924	<.001	36	view →
OV	OS	Median	II,III,IV	0.330	0.843	.002	18	view →
SKCM	DFS	Median	All	1.000	0.609	.002	17	view →
SCLC	OS	Median	All	0.055	0.708	<.001	12	view →
ACC	OS	Median	All	0.147	0.685	.018	12	view →
LIHC	DFS	Median	All	0.079	0.557	<.001	12	view →
ESCA	DFS	Median	All	0.191	0.538	.012	12	view →
LUSC	OS	Median	II,III,IV	0.283	0.633	.023	12	view →
READ	OS	Median	All	0.579	0.939	.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

SOCS5–BRCA (OS)

Open the BRCA breakdown →