SOCS5

Across TCGA patient cohorts, SOCS5 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOCS5-associated genes across cancer lineages are 14-3-3_beta, FASN, and Fibronectin. Each is linked with SOCS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS5-to-partner and partner-to-SOCS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SOCS5-low versus SOCS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS5→partner) and Y-score (partner→SOCS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.096	-2.780	.003	.003	3	2
UCEC	FASN →	+0.287	+1.874	.025	.049	3	2
UCEC	Fibronectin →	-0.260	-1.352	.015	.034	3	2
UCEC	FoxM1 →	+0.263	+1.716	.001	.003	3	2
UCEC	ASNS →	+0.356	+1.807	.002	.024	3	2
UCEC	ATM →	-0.552	-2.401	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

14-3-3_beta by SOCS5 expression — UCEC

Explore this box plot interactively →