SOCS5

Across TCGA cell cohorts, SOCS5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SOCS5-associated genes across cancer lineages are FAM71A, RAX2, and H1-8. Each is linked with SOCS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS5-to-partner and partner-to-SOCS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71A grouped by SOCS5-low versus SOCS5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS5→partner) and Y-score (partner→SOCS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM71A →	+0.054	+3.453	.004	.009	3	1
LARGE_INTESTINE	RAX2 →	+0.077	+3.196	<.001	.007	3	1
CNS	H1-8 →	+0.022	+5.357	<.001	.001	3	1
BLOOD_Leukemia	MYH2 →	+0.029	+5.201	<.001	.006	3	1
LUNG_NSCLC_LUAD	SLC35G4 →	+0.022	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	MTRNR2L10 →	+0.010	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FAM71A by SOCS5 expression — LARGE_INTESTINE

Explore this box plot interactively →