SOCS5

Across TCGA cell cohorts, SOCS5 mutation is significantly associated with the mutation status of many other genes, with 3,034 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOCS5-associated genes across cancer lineages are CEMIP2, TNRC6A, and ADCY5. Each is linked with SOCS5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SOCS5-to-partner and partner-to-SOCS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEMIP2 grouped by SOCS5-low versus SOCS5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS5→partner) and Y-score (partner→SOCS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CEMIP2 →	+4.339	+4.339	.009	.009	1	4
BLOOD_Leukemia	TNRC6A →	+2.672	+4.225	.008	.008	1	3
BLOOD_Leukemia	ADCY5 →	+2.672	+4.225	.008	.008	1	3
BLOOD_Leukemia	KCND2 →	+5.894	+5.321	.002	.002	1	3
LARGE_INTESTINE	NACA →	+2.611	+4.372	<.001	<.001	1	3
BLOOD_Leukemia	OGDHL →	+3.020	+4.545	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,034 associations by consensus.

CEMIP2 by SOCS5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →