Across TCGA patient cohorts, SOCS3 RNA expression is significantly associated with the RNA expression of many other genes, with 17,706 significant associations in total. UVM shows the largest number of these associations.

The most reproducible SOCS3-associated genes across cancer lineages are SLC2A3, OSM, and FOSB. Each is linked with SOCS3 in more than 33 cancer types. Because this analysis shows association rather than direction, both SOCS3-to-partner and partner-to-SOCS3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS3→partner) and Y-score (partner→SOCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	SLC2A3 →	+2.355	+1.292	<.001	<.001	3	34
CHOL	OSM →	+2.015	+2.494	<.001	<.001	3	34
MESO	FOSB →	+3.600	+1.644	<.001	<.001	3	34
PCPG	ZFP36 →	+2.567	+2.684	<.001	<.001	3	34
MESO	FOS →	+2.796	+1.511	<.001	<.001	3	34
BLCA	ICAM1 →	+1.983	+1.715	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,706 associations by consensus.

Exploration

SOCS3 survival (RNA) · tumor vs normal (RNA) · all SOCS3 data types