Across TCGA patient cohorts, SOCS3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOCS3-associated genes across cancer lineages are VHL, JNK_pT183_Y185, and Tuberin_pT1462. Each is linked with SOCS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOCS3-to-partner and partner-to-SOCS3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS3→partner) and Y-score (partner→SOCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.219	-3.321	<.001	.010	3	3
UCEC	JNK_pT183_Y185 →	-0.256	-3.308	.003	.010	3	1
UCEC	Tuberin_pT1462 →	+0.273	+2.817	.024	.036	3	1
UCEC	Tuberin →	+0.389	+2.817	.005	.036	3	1
UCEC	eIF4G →	+0.379	+3.321	.020	.010	2	1
UCEC	Cyclin-B1 →	+0.937	+3.000	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

SOCS3 survival (RNA) · tumor vs normal (RNA) · all SOCS3 data types