Across TCGA cell cohorts, SOCS3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SOCS3-associated genes across cancer lineages are NKX2-6, TLE7, and XAGE5. Each is linked with SOCS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS3-to-partner and partner-to-SOCS3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS3→partner) and Y-score (partner→SOCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

SOCS3 survival (RNA) · tumor vs normal (RNA) · all SOCS3 data types