SOCS2

Across TCGA patient cohorts, SOCS2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,240 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SOCS2-associated genes across cancer lineages are SOCS2-AS1, C7, and SLC4A4. Each is linked with SOCS2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SOCS2-to-partner and partner-to-SOCS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOCS2 versus SOCS2-AS1 in GBM, with a Pearson correlation of 0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS2→partner) and Y-score (partner→SOCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOCS2-AS1 →	+1.338	+1.062	<.001	<.001	3	5
BRCA	C7 →	+2.118	+0.719	<.001	.009	3	3
UCEC	SLC4A4 →	+1.373	+0.606	<.001	<.001	3	3
UCEC	GLI1 →	+0.928	+0.496	<.001	.003	3	2
BRCA	RERGL →	+1.290	+0.833	.001	<.001	3	2
BRCA	SATB2 →	+0.655	+0.868	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,240 associations by consensus.

SOCS2 vs SOCS2-AS1 — GBM

Explore this scatter interactively →