SOCS2

Across TCGA patient cohorts, SOCS2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOCS2-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FoxM1. Each is linked with SOCS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS2-to-partner and partner-to-SOCS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SOCS2-low versus SOCS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS2→partner) and Y-score (partner→SOCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.233	-1.700	.029	.044	3	1
UCEC	eIF4E →	+0.227	+3.183	.011	.009	3	1
UCEC	FoxM1 →	+0.251	+2.179	.022	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.119	-1.990	.024	.030	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.540	+2.469	.012	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.202	-2.321	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EGFR_pY1068 by SOCS2 expression — UCEC

Explore this box plot interactively →