SOCS1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SOCS1 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOCS1-associated genes across cancer lineages are RNU6-939P, CROCCP4, and RNA5SP419. Each is linked with SOCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS1-to-partner and partner-to-SOCS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS1→partner) and Y-score (partner→SOCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
DLBCRNU6-939P →+0.758+3.710.002.00832
UCECCROCCP4 →+0.182+2.797<.001.00532
UCECRNA5SP419 →+0.977+3.398<.001.00132
UCECRNA5SP413 →+1.944+3.277<.001.00132
UCECRNA5SP417 →+0.858+3.029<.001.00532
UCECRNA5SP420 →+0.951+3.289<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

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