Across TCGA patient cohorts, SOCS1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOCS1-associated genes across cancer lineages are p62 Lck ligand, PKC-a_pS657, and VEGFR2. Each is linked with SOCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS1-to-partner and partner-to-SOCS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS1→partner) and Y-score (partner→SOCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.694	+2.817	<.001	.036	2	1
UCEC	PKC-a_pS657 →	+0.599	+2.820	.010	.036	2	1
UCEC	VEGFR2 →	+0.602	+2.820	<.001	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

SOCS1 survival (RNA) · tumor vs normal (RNA) · all SOCS1 data types