Across TCGA cell cohorts, SOCS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,452 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOCS1-associated GO terms across cancer lineages are Negative regulation of CD8-positive, alpha-beta T cell differentiation, Positive regulation of canonical NF-kappaB signal transduction, and Negative regulation of response to biotic stimulus. Each is linked with SOCS1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SOCS1-to-partner and partner-to-SOCS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS1→partner) and Y-score (partner→SOCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of CD8-positive, alpha-beta T cell differentiation →	-0.325	-1.451	<.001	<.001	3	14
BONE	Positive regulation of canonical NF-kappaB signal transduction →	+0.060	+1.062	<.001	.002	3	12
SOFT_TISSUE	Negative regulation of response to biotic stimulus →	+0.054	+0.910	.004	.005	3	10
PANCREAS	Negative regulation of innate immune response →	+0.098	+0.672	<.001	.003	2	11
BONE	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.235	+1.190	<.001	.004	3	9
URINARY_TRACT	PML body organization →	+0.180	+0.618	<.001	.003	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,452 associations by consensus.

Exploration

SOCS1 survival (RNA) · tumor vs normal (RNA) · all SOCS1 data types