SOBP

Across TCGA pan-cancer cohorts, SOBP Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SOBP data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SOBP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SOBP expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

HNSC, KIRC, and SARC are the cancer types where SOBP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.179	0.688	<.001	48	view →
KIRC	OS	Median	All	0.459	0.806	.014	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
STAD	DFS	Median	III,IV	0.118	0.580	.009	3	view →
SKCM	DFS	Median	IV	1.000	0.201	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SOBP–HNSC (OS)

Open the HNSC breakdown →