SOBP

Across TCGA patient cohorts, SOBP mutation is significantly associated with the RNA expression of many other genes, with 5,122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOBP-associated genes across cancer lineages are GNPNAT1, RNA5SP411, and PPY2P. Each is linked with SOBP in more than 3 cancer types. Because this analysis shows association rather than direction, both SOBP-to-partner and partner-to-SOBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by SOBP-low versus SOBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOBP→partner) and Y-score (partner→SOBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNPNAT1 →	+0.592	+2.102	<.001	<.001	3	4
UCEC	RNA5SP411 →	+0.655	+1.634	.002	.001	3	3
CESC	PPY2P →	+0.310	+2.819	<.001	.002	3	3
READ	CDK8P1 →	+0.112	+5.039	.001	.008	3	3
SKCM	CDK2AP1 →	+0.719	+3.208	.001	.009	3	3
BRCA	OR6X1 →	+0.040	+4.215	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,122 associations by consensus.

GNPNAT1 by SOBP expression — UCEC

Explore this box plot interactively →