SOBP

Across TCGA patient cohorts, SOBP mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOBP-associated genes across cancer lineages are Ku80, ATM, and 14-3-3_beta. Each is linked with SOBP in more than 2 cancer types. Because this analysis shows association rather than direction, both SOBP-to-partner and partner-to-SOBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SOBP-low versus SOBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOBP→partner) and Y-score (partner→SOBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.305	+2.214	<.001	<.001	3	3
UCEC	ATM →	-0.417	-2.571	.006	.010	3	3
UCEC	14-3-3_beta →	-0.081	-1.673	.015	.040	3	2
UCEC	EGFR →	-0.191	-2.321	<.001	.005	3	2
UCEC	FoxM1 →	+0.261	+1.874	.002	.002	3	2
UCEC	ACC_pS79 →	+0.310	+1.321	.007	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Ku80 by SOBP expression — UCEC

Explore this box plot interactively →