SOBP

Across TCGA cell cohorts, SOBP mutation is significantly associated with the RNA expression of many other genes, with 738 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOBP-associated genes across cancer lineages are OR11H6, REG3G, and TTI2. Each is linked with SOBP in more than 1 cancer types. Because this analysis shows association rather than direction, both SOBP-to-partner and partner-to-SOBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by SOBP-low versus SOBP-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOBP→partner) and Y-score (partner→SOBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.018	+4.321	<.001	.009	3	2
BLOOD_Lymphoma	REG3G →	+0.026	+4.867	.004	.009	3	2
LARGE_INTESTINE	TTI2 →	+0.784	+2.949	<.001	<.001	3	2
LARGE_INTESTINE	PGBD1 →	+0.625	+2.265	.003	.001	3	2
LARGE_INTESTINE	MED9 →	+0.373	+2.351	.007	.001	3	2
LARGE_INTESTINE	POMGNT2 →	+0.739	+3.321	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 738 associations by consensus.

OR11H6 by SOBP expression — CNS

Explore this box plot interactively →