SOBP

Across TCGA cell cohorts, SOBP mutation is significantly associated with the mutation status of many other genes, with 5,636 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOBP-associated genes across cancer lineages are BPTF, USP35, and AFF2. Each is linked with SOBP in more than 5 cancer types. Because this analysis shows association rather than direction, both SOBP-to-partner and partner-to-SOBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPTF grouped by SOBP-low versus SOBP-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOBP→partner) and Y-score (partner→SOBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BPTF →	+3.169	+4.601	.003	.003	1	6
BLOOD_Leukemia	USP35 →	+2.232	+2.282	.006	.006	1	6
BLOOD_Leukemia	AFF2 →	+2.758	+2.493	.007	.007	1	6
BLOOD_Lymphoma	GNAS →	+3.362	+4.754	.002	.002	1	5
BLOOD_Lymphoma	MYO1D →	+4.584	+4.584	.007	.007	1	5
BLOOD_Lymphoma	ZBTB2 →	+5.584	+5.014	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,636 associations by consensus.

BPTF by SOBP expression — BLOOD_Lymphoma

Explore this box plot interactively →