SOAT2

Across TCGA patient cohorts, SOAT2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOAT2-associated genes across cancer lineages are p62 Lck ligand, S6_pS240_S244, and 14-3-3_beta. Each is linked with SOAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOAT2-to-partner and partner-to-SOAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SOAT2-low versus SOAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOAT2→partner) and Y-score (partner→SOAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.243	+2.125	.031	.010	3	2
UCEC	S6_pS240_S244 →	+0.305	+1.440	.030	.024	3	2
UCEC	14-3-3_beta →	-0.078	-3.432	.024	.005	3	1
UCEC	eEF2 →	+0.421	+2.906	<.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.321	-2.938	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.117	-2.321	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

p62 Lck ligand by SOAT2 expression — UCEC

Explore this box plot interactively →