Across TCGA pan-cancer cohorts, SNX9-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SNX9-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where SNX9-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SNX9-AS1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.
KICH, BRCA, and PAAD are the cancer types where SNX9-AS1 tumor–normal differential expression is most reproducible.