SNX8

Across TCGA patient cohorts, SNX8 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX8-associated genes across cancer lineages are eEF2, Smac, and Caspase-7-cleavedD198. Each is linked with SNX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX8-to-partner and partner-to-SNX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SNX8-low versus SNX8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX8→partner) and Y-score (partner→SNX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.531	+2.584	.001	.011	3	2
UCEC	Smac →	+0.313	+2.584	.009	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.886	+2.341	.001	.019	3	2
UCEC	EGFR_pY1068 →	-0.301	-2.584	.009	.011	3	1
UCEC	GAPDH →	+0.655	+3.321	.008	.010	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.647	+3.469	.006	.002	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eEF2 by SNX8 expression — UCEC

Explore this box plot interactively →