SNX8

Across TCGA cell cohorts, SNX8 mutation is significantly associated with the mutation status of many other genes, with 2,373 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNX8-associated genes across cancer lineages are PLCL1, EPAS1, and ZNF831. Each is linked with SNX8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNX8-to-partner and partner-to-SNX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLCL1 grouped by SNX8-low versus SNX8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX8→partner) and Y-score (partner→SNX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLCL1 →	+3.247	+3.050	.008	.008	1	3
BLOOD_Leukemia	EPAS1 →	+3.662	+3.523	<.001	<.001	1	3
BLOOD_Leukemia	ZNF831 →	+2.493	+2.758	.007	.007	1	3
BLOOD_Leukemia	GPR158 →	+2.814	+3.282	<.001	<.001	1	3
BLOOD_Leukemia	EPG5 →	+2.662	+2.887	.005	.005	1	3
BLOOD_Leukemia	SPTBN4 →	+2.493	+2.758	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,373 associations by consensus.

PLCL1 by SNX8 expression — BLOOD_Leukemia

Explore this box plot interactively →